Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease

This study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson's disease using structural functional MRI. We investigated resting-state connectivity important subdivisions the caudate nucleus, putamen thalamus, also how morphology these structures are impacted disorder. found cognitively unimpaired subjects (n = 33), compared to controls 26), display increased dorsal caudate, anterior mediodorsal thalamic areas across frontal lobe, as well reduced posterior cortical cerebellar regions. Compared subjects, those mild 22) demonstrated thalamus paracingulate cortex, while demonstrating cingulate 17). Extensive volumetric surface-based deflation was participants controls. Our research suggests that within basal ganglia-thalamocortical circuits implicated disease, breakdown para- regions brain respectively.